[Gastrointestinal and abdominal Tuberculosis in Golestan-Iran: a 5-years report]

15-20% of TB cases are extra pulmonary tuberculosis [EPTB]. Abdominal TB is the most common type of extra intestinal TB. Signs and symptoms of abdominal TB are unspecific. In this study, we identified all GITB cases in Golestan province [Iran] between 1999 and 2003 and determined their demographic characteristics. We reviewed all new cases of TB reported during 1999-2003 from TB centers of Golestan province.Then EPTB and especially GI and abdominal TB cases were selected. We completed a questionnaire containing demographic information for each of them. The information entered the computer in SPSS-13 was used to analyze the data. 30 patients had been treated for GI and abdominal TB, most of them were females [22 cases, 73.3%]. Mean age of the patients was 32.03 +/- 13.73 with higher incidence in age before 40 years old [70%]. Most common complaints of the patients were fatigue, weight loss, anorexia, fever and abdominal pain, respectively. In 66.7% of patients the diagnosis was pathologically documented. Our data suggest that 38.46% of all TB cases in Golestan province were EPTB, and this scale is higher than other studies. In this study, 5.27% of EPTB cases were GI and abdominal TB, higher than the world reports [3%]

[Seroepidemiology of celiac disease among blood donor in Golestan province]

Celiac is a digestive disease. In this disease, small bowel is damaged and the absorption of nutrients are adversely affected. These patients do not absorb gluten. There is probably a correlation between esophagus cancer and celiac. The aim of this research was to study the seroepidemiology celiac disease in this area with high prevalency of esophagus cancer. This research was a descriptive study, which was performed on blood donors in Golestan province during the year 2005-06. blood samples were taken from 2547 subjects. tTG-IgA determination were carried out using ElISA technique, the titre<4U/ml, 4-10U/ml and >10Um/l were considered to be as negative, weakly positive and positive respectively. EMA antibody assessment were carried out on all sample population with more than 4U/ml, using IFA method. 28 subjects [1.1%] had tTG-Ab positive test, out of this number 18 subjects [0.7%] were weakly positive and 10 persons [0.4%] were considered to be positive. EMA test were positive in 70% of subjects with tTG positive results. There was not any significant meaning between positive tTG test and ethnicity from weakly positive tTG, 15 subjects [83.3%] and 3 subjects [16.7%] were male and female respectively. The entire tTG positive were male subjects. In regard to high prevalency of esophagus cancer in the region and the relation of celiac disease with above cancer, it seems necessary to look more seriously at the celiac disease

[ epidemiological aspect of colorectal cancer in Gorgan]

Background and Objective: colorectal cancer is the most common cancer of GI and 2nd most common cause of cancer death in the world. The purpose of this study was to determine epidemiologic aspect and tumor characteristics of colorectal cancer for patients and compare them in young [<50 yr] and older [>50 yr] patients

Materials and Methods: in this cross-sectional study during 3 yr the samples of malignant colorectal cancer presented in Gorgan endoscopy and pathologic centers were collected. Data evaluated by statistically method

Results: there were 101 cases of malignant colorectal cancer. 61 cases were male and 40 cases were female. The mean age was 56+/-13.65 yr. 13.9% of patients were <40 yr. The type of tumor in 94% was adenocarcinoma, 2.9% lymphoma and 2.9% undifferentiated carcinoma. The site of involvement in 30 cases were rectum and in 71 cases were colon. The most common symptom was abdominal pain, constipation and rectal bleeding. The time interval between onset of symptom to diagnosis of disease in 58 cases was >6 mth. Family history of cancer in 36 cases was positive. Right colon cancer in young patient was significantly more than older [P<0.05]. Positive family history of cancer in right colon cancer was significantly more other than. Positive family history of cancer in young patient was more than other [P<0.05]

Conclusion: according to this study, colorectal cancer was high. Therefore, it is necessary to pay more attention to the symptom of young patient and providing a screening program in patients over 50 years old and young patients with positive family history

[Comparison of Imipramine, Desmopresine and conditional therapy in enuresis treatment of children]

Background and Objective: enuresis is a problem in children. In this research the success, rate and recurrence of Imipramine, Desmopresine and conditional therapy has been studied in enuresis treatment of children

Materials and Methods: this study was done on 84 enuresis child between 7-11 years old which were selected by screening at the schools. Patients divided randomly to 3 groups: The 1st group received 25 mg of Imipramine every night. The 2nd group was treated with 20 micg of Desmopresine intranasaly every night. The 3rd group used alarm for conditioning every night. All groups were treated for one month, and 2 weeks without enuresis meaned success

Results: all physical finding and laboratory tests were normal in all patients [FBS, U/A, U/C, kidney and bladder sonography]. Patients had in average 8.5 years old. 77.3% of cases were boys and 22.7% were girls. Success rate for therapy was 71.4%, 60% and 50% in-groups 1-3 respectively. Recurrence rate 6 months after therapy was 10%, 55.5% and 25% in-groups 1-3 respectively

Conclusion: imipramine persists as cheep, available, well-tolerated and effective way of treating enuretic patients. Due to high recurrence rate, Desmopresine is just recommended as a temporary treatment